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Article

An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2.

The Journal of biological chemistry - 2 Dec 2005

Gerard Norma P, Lu Bao, Liu Pixu, Craig Stewart, Fujiwara Yuko, Okinaga Shoji, Gerard Craig

Abstract excerpt

C5L2 is an enigmatic serpentine receptor that is co-expressed with the C5a receptor on many cells including polymorphonuclear neutrophils. The apparent absence of coupling of C5L2 with G proteins suggests that this receptor may modulate the biological activity of C5a, perhaps by acting as a decoy receptor. Alternatively, C5L2 may affect C5a function through formation of a heteromeric complex with the C5aR, or it...

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Identifiers

PMID: 16204243
DOI: 10.1074/jbc.C500287200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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