Article
CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.
Molecular cell - 8 Oct 2010
Centore Richard C, Havens Courtney G, Manning Amity L, Li Ju-Mei, Flynn Rachel Litman, Tse Alice, Jin Jianping, Dyson Nicholas J, Walter Johannes C, Zou Lee
Abstract excerpt
The proper coordination between DNA replication and mitosis during cell-cycle progression is crucial for genomic stability. During G2 and mitosis, Set8 catalyzes monomethylation of histone H4 on lysine 20 (H4K20me1), which promotes chromatin compaction. Set8 levels decline in S phase, but why and how this occurs is unclear. Here, we show that Set8 is targeted for proteolysis in S phase and in response to DNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.