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Article

Novel metabolic phenotypes in lecithin cholesterol acyltyransferase-deficient mice.

Current opinion in lipidology - 1 Apr 2018

Ng Dominic S

Abstract excerpt

PURPOSE OF REVIEW: Lecithin cholesterol acyltyransferase (LCAT) deficiency is a rare monogenic disorder causing lipoprotein dysregulation and multiple organ dysfunctions, including renal impairment. LCAT knockout mice have been shown informative in elucidating mechanisms of many major clinical morbid phenotypes. Extended characterization of the LDL receptor/LCAT double knockout (Ldlr/Lcat-DKO or DKO) mice had led...

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Source

Identifiers

PMID: 29369831
DOI: 10.1097/MOL.0000000000000486

Genes

LCAT
PRDM16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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