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Article

Ligand-dependent transcriptional induction of lethal autophagy: A new perspective for cancer treatment

25 Jan 2018

Abstract excerpt

Dendrogenin A (DDA) is a mammalian metabolite that displays anticancer and chemopreventive properties in mice. At the cancer cell level, DDA induces differentiation and death. We investigated herein the nature of DDA cytoxicity in cancer cells. We showed that DDA triggers biochemical and cellular features of macroautophagy/autophagy and that autophagy is cytotoxic. DDA induces both the accumulation of...

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PMID: 29368971
DOI: 10.1080/15548627.2018.1425059

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