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Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer

9 Jun 2025

Abstract excerpt

Chaperone-mediated autophagy (CMA), a type of selective degradation of cytosolic proteins in lysosomes, is commonly upregulated in cancer cells, contributing to their survival and growth. The lack of a specific target for CMA inhibition has limited CMA blockage to genetic manipulations or global lysosomal function inhibition. Here, using genetic modulation, transcriptional analysis, and functional studies, we...

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PMID: 40490560
DOI: 10.1038/s44321-025-00254-y

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