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Article

Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer

23 Jan 2018

Abstract excerpt

Steroid receptor coactivator 1 (SRC-1) interacts with nuclear receptors and other transcription factors (TFs) to initiate transcriptional networks and regulate downstream genes which enable the cancer cell to evade therapy and metastasise. Here we took a top-down discovery approach to map out the SRC-1 transcriptional network in endocrine resistant breast cancer. First, rapid immunoprecipitation mass spectrometry...

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PMID: 29367763
DOI: 10.1038/s41388-017-0042-x

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