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The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness

20 Oct 2020

Abstract excerpt

The p140Cap adaptor protein is a scaffold molecule encoded by the SRCIN1 gene, which is physiologically expressed in several epithelial tissues and in the neurons. However, p140Cap is also strongly expressed in a significant subset of cancers including breast cancer and neuroblastoma. Notably, cancer patients with high p140Cap expression in their primary tumors have a lower probability of developing a distant...

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PMID: 33079227
DOI: 10.1007/s00018-020-03666-w

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