Tumor Heterogeneity—A ‘Contemporary Concept’ Founded on Historical Insights and Predictions

Abstract excerpt

Heterogeneity is commonplace in all cancer types and at several levels--intrinsic (genetic), epigenetic, positional, and at the population level. The different subpopulations with a tumor mass communicate with each other and influence the behavior of other tumor cells both locally and at a distance. These properties have profound implications regarding the understanding of tumor behavior and how therapies are (or...

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