Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGF-β signaling pathway and breast cancer susceptibility.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2011

Scollen Serena, Luccarini Craig, Baynes Caroline, Driver Kristy, Humphreys Manjeet K, Garcia-Closas Montserrat, Figueroa Jonine, Lissowska Jolanta, Pharoah Paul D, Easton Douglas F, Hesketh Robin, Metcalfe James C, Dunning Alison M

Abstract excerpt

BACKGROUND: TGF-β acts as a suppressor of primary tumor initiation but has been implicated as a promoter of the later malignant stages. Here associations with risk of invasive breast cancer are assessed for single-nucleotide polymorphisms (SNP) tagging 17 genes in the canonical TGF-β ALK5/SMADs 2&3 and ALK1/SMADs 1&5 signaling pathways: LTBP1, LTBP2, LTBP4, TGFB1, TGFB2, TGFB3, TGFBR1(ALK5), ALK1, TGFBR2,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Neoplasm Invasiveness

Share to Neoplasm Staging

Share to Prognosis

Share to Signal Transduction

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 21527583
DOI: 10.1158/1055-9965.EPI-11-0062
PMCID: PMC3112459

Genes

TGFB1
TGFBR1
TGFBR2
ACVRL1
ENG
IMPACT
LTBP1
LTBP2
LTBP4
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMAD7
TGFB2
TGFB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGF-β signaling pathway and breast cancer susceptibility.PMID 21527583Read ↗

Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians.Semantic proximity Read ↗

TGFBR1*6A as a modifier of breast cancer risk and progression: advances and future prospectsSemantic proximity Read ↗

Transforming growth factor beta 1 (TGFβ1) polymorphisms and haplotype structures have dual roles in breast cancer pathogenesis.Semantic proximity Read ↗

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β SuperfamilySemantic proximity Read ↗

Identification of molecular subtypes and prognostic features of breast cancer based on TGF-β signaling-related genesSemantic proximity Read ↗

Association between the TGFBR2 G-875A polymorphism and cancer risk: evidence from a meta-analysis.Semantic proximity Read ↗

Alterations in components of the TGF-β superfamily signaling pathways in human cancerSemantic proximity Read ↗

TGFBR1 signaling and breast cancer.Semantic proximity Read ↗

TGFβ Signaling in Growth Control, Cancer, and Heritable DisordersSemantic proximity Read ↗

Beyond TGFβ: roles of other TGFβ superfamily members in cancerSemantic proximity Read ↗

The influence of genetic ancestry and ethnicity on breast cancer survival associated with genetic variation in the TGF-β-signaling pathway: The Breast Cancer Health Disparities Study.Semantic proximity Read ↗

Molecular Pathways: Targeting the TGF-β Pathway for Cancer TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.