Article
Clinicopathological characteristics and mutation profiling in primary cutaneous melanoma.
The American Journal of dermatopathology - 1 May 2015
Yaman Banu, Akalin Taner, Kandiloğlu Gülşen
Abstract excerpt
BACKGROUND: The incidence of mutations in malignant melanoma varies remarkably according to the subtype of melanoma, and this in itself is affected by racial and geographical factors. Studies screening melanoma case series for different types of mutations are relatively rare. METHOD: The authors analyzed the frequency of various somatic point mutations of 10 genes in 106 primary cutaneous melanoma cases. The...
Topics
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Chi-Square Distribution
- DNA Mutational Analysis
- Female
- GTP Phosphohydrolases
- Gene Frequency
- Genes, p16
- Genetic Predisposition to Disease
- Humans
- Logistic Models
- Male
- Melanoma