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Twin DNA Methylation Profiling Reveals Flare‐Dependent Interferon Signature and B Cell Promoter Hypermethylation in Systemic Lupus Erythematosus

23 Jan 2018

Abstract excerpt

OBJECTIVE: Systemic lupus erythematosus (SLE) has limited monozygotic twin concordance, implying a role for pathogenic factors other than genetic variation, such as epigenetic changes. Using the disease-discordant twin model, we investigated genome-wide DNA methylation changes in sorted CD4+ T cells, monocytes, granulocytes, and B cells in twin pairs with at least 1 SLE-affected twin. METHODS: Peripheral blood...

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PMID: 29361205
DOI: 10.1002/art.40422

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