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Article

Homodimer formation by the ATP/UTP receptor P2Y2 via disulfide bridges.

Journal of biochemistry - 1 Jun 2018

Abe Maya, Watanabe Kanae, Kuroda Yoshiyuki, Nakagawa Tetsuto, Higashi Hideyoshi

Abstract excerpt

Many class C G-protein coupled receptors (GPCRs) function as homo- or heterodimers and several class A GPCRs have also been shown to form a homodimer. We expressed human P2Y2 receptor (P2Y2R) in cultured cells and compared SDS-PAGE patterns under reducing and non-reducing conditions. Under non-reducing conditions, approximately half of the P2Y2Rs were electrophoresed as a dimer. We then produced Cys to Ser...

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PMID: 29361137
DOI: 10.1093/jb/mvy010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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