Article
The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2006
Savi Pierre, Zachayus Jean-Luc, Delesque-Touchard Nathalie, Labouret Catherine, Hervé Caroline, Uzabiaga Marie-Françoise, Pereillo Jean-Marie, Culouscou Jean-Michel, Bono Françoise, Ferrara Pascual, Herbert Jean-Marc
Abstract excerpt
P2Y12, a G protein-coupled receptor that plays a central role in platelet activation has been recently identified as the receptor targeted by the antithrombotic drug, clopidogrel. In this study, we further deciphered the mechanism of action of clopidogrel and of its active metabolite (Act-Met) on P2Y12 receptors. Using biochemical approaches, we demonstrated the existence of homooligomeric complexes of P2Y12...
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