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Article

Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2.

The Journal of biological chemistry - 4 Nov 2005

Henriksen Ulla, Fog Jacob U, Litman Thomas, Gether Ulrik

Abstract excerpt

ABCG2 is an ATP binding cassette (ABC) half-transporter that plays a key role in multidrug resistance to chemotherapy. ABCG2 is believed to be a functional homodimer that has been proposed to be linked by disulfide bridges. We have investigated the structural and functional role of the only three cysteines predicted to be on the extracellular face of ABCG2. Upon mutation of Cys-592 or Cys-608 to alanine (C592A...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16107343
DOI: 10.1074/jbc.M502937200

Genes

ABCG2
SDS

Variants

Provenance

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