Article
Oligomerization of the alpha and beta isoforms of the thromboxane A2 receptor: relevance to receptor signaling and endocytosis.
Cellular signalling - 1 Nov 2005
Laroche Geneviève, Lépine Marie-Claude, Thériault Caroline, Giguère Patrick, Giguère Vincent, Gallant Maxime A, de Brum-Fernandes Artur, Parent Jean-Luc
Abstract excerpt
Thromboxane A(2) (TXA(2)) is a potent mediator of inflammation, vasoconstriction and oxidative stress. The TXA(2) receptor (TP) is a G protein-coupled receptor (GPCR) that is expressed as two alternatively spliced isoforms, alpha (343 residues) and beta (407 residues) that share the first 328 residues. For many years GPCRs were assumed to exist and function as monomeric species, but increasing evidence suggests...
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