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Article

Epigenetic Alterations in Bone and Soft Tissue Tumors.

Advances in anatomic pathology - 1 Nov 2017

Wojcik John, Cooper Kumarasen

Abstract excerpt

Human malignancies are driven by heritable alterations that lead to unchecked cellular proliferation, invasive growth and distant spread. Heritable changes can arise from changes in DNA sequence, or, alternatively, through altered gene expression rooted in epigenetic mechanisms. In recent years, high-throughput sequencing of tumor genomes has revealed a central role for mutations in epigenetic regulatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28885261
DOI: 10.1097/PAP.0000000000000167
PMCID: PMC5657591

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