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Restoration of Olfactory Memory in Drosophila Overexpressing Human Alzheimer’s Disease Associated Tau by Manipulation of L-Type Ca2+ Channels

10 Sept 2019

Abstract excerpt

The cellular underpinnings of memory deficits in Alzheimer’s disease (AD) are poorly understood. We utilised the tractable neural circuits sub-serving memory in Drosophila to investigate the role of impaired Ca2+ handling in memory deficits caused by expression of human 0N4R isoform of tau which is associated with AD. Expression of tau in the entire mushroom body or parts of it as well as in mushroom body output...

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PMID: 31551716
DOI: 10.3389/fncel.2019.00409

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