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Article

LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase-dependent proteolysis of the stem-cell protein SOX2.

The Journal of biological chemistry - 9 Mar 2018

Zhang Chunxiao, Hoang Nam, Leng Feng, Saxena Lovely, Lee Logan, Alejo Salvador, Qi Dandan, Khal Anthony, Sun Hong, Lu Fei, Zhang Hui

Abstract excerpt

The pluripotency-controlling stem-cell protein SRY-box 2 (SOX2) plays a pivotal role in maintaining the self-renewal and pluripotency of embryonic stem cells and also of teratocarcinoma or embryonic carcinoma cells. SOX2 is monomethylated at lysine 119 (Lys-119) in mouse embryonic stem cells by the SET7 methyltransferase, and this methylation triggers ubiquitin-dependent SOX2 proteolysis. However, the molecular...

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Share to Chromosomal Proteins, Non-Histone
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histone-Lysine N-Methyltransferase

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Source

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Identifiers

PMID: 29358331
DOI: 10.1074/jbc.RA117.000342
PMCID: PMC5846134

Genes

SOX2
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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