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The FBXW2–MSX2–SOX2 axis regulates stem cell property and drug resistance of cancer cells

23 Sept 2019

Abstract excerpt

SOX2 is a key transcription factor that plays critical roles in maintaining stem cell property and conferring drug resistance. However, the underlying mechanisms by which SOX2 level is precisely regulated remain elusive. Here we report that MLN4924, also known as pevonedistat, a small-molecule inhibitor of neddylation currently in phase II clinical trials, down-regulates SOX2 expression via causing accumulation...

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PMID: 31548378
DOI: 10.1073/pnas.1905973116

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