Article
Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2010
Holmes Avram J, Bogdan Ryan, Pizzagalli Diego A
Abstract excerpt
A variable number of tandem repeats (short (S) vs long (L)) in the promoter region of the serotonin transporter gene (5-HTTLPR) and a functional variant of a single-nucleotide polymorphism (rs25531) in 5-HTTLPR have been recently associated with increased risk for major depressive disorder (MDD). In particular, relative to L/L or L(A) homozygotes (hereafter referred to as L' participants), S carriers or...
Topics
- Brain
- Brain Mapping
- Major Depressive Disorder
- Executive Function
- Female
- Genetic Predisposition to Disease
- Genotype
- Gyrus Cinguli