Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression.

doi:10.1038/npp.2009.223

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Article

Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2010

Holmes Avram J, Bogdan Ryan, Pizzagalli Diego A

Abstract excerpt

A variable number of tandem repeats (short (S) vs long (L)) in the promoter region of the serotonin transporter gene (5-HTTLPR) and a functional variant of a single-nucleotide polymorphism (rs25531) in 5-HTTLPR have been recently associated with increased risk for major depressive disorder (MDD). In particular, relative to L/L or L(A) homozygotes (hereafter referred to as L' participants), S carriers or...

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PMID: 20090673
DOI: 10.1038/npp.2009.223
PMCID: PMC2840070

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