Article
5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation.
Biological psychology - 1 Apr 2011
Lonsdorf Tina B, Golkar Armita, Lindstöm Kara M, Fransson Peter, Schalling Martin, Ohman Arne, Ingvar Martin
Abstract excerpt
Amygdala reactivity is a heritable trait, potentiated in affective disorders and associated with both the 5-HTTLPR and the COMTval158met polymorphism. Fifty-four healthy volunteers selected a priori based on gender and 5-HTTLPR/rs25531 and COMTval158met genotypes performed a passive viewing task of angry facial expressions using fMRI. Amygdala reactivity and habituation were investigated using the a priori...
Topics
- Adult
- Amygdala
- Catechol O-Methyltransferase
- Face
- Female
- Galvanic Skin Response
- Genotype
- Habituation, Psychophysiologic
- Humans
- Hydrocortisone
- Image Processing, Computer-Assisted