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Circulating cell-free DNA methylation patterns indicate cellular sources of allograft injury after liver transplant

17 Jun 2025

Abstract excerpt

Post-transplant complications reduce allograft and recipient survival. Current approaches for detecting allograft injury non-invasively are limited and do not differentiate between cellular mechanisms. Here, we monitor cellular damages after liver transplants from cell-free DNA (cfDNA) fragments released from dying cells into the circulation. We analyzed 130 blood samples collected from 44 patients at different...

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PMID: 40527875
DOI: 10.1038/s41467-025-60507-9

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