Article
Circulating cell-free DNA methylation analysis of pancreatic cancer patients for early noninvasive diagnosis
10 Mar 2025
Abstract excerpt
Background: Aberrant hypermethylation of genomic DNA CpG islands (CGIs) is frequently observed in human pancreatic cancer (PAC). A plasma cell-free DNA (cfDNA) methylation analysis method can be utilized for the early and noninvasive detection of PAC. This study also aimed to differentiate PAC from other cancer types. Methods: We employed the methylated CpG tandem amplification and sequencing (MCTA-Seq) method,...