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Article

Evaluation of circulating cell-free DNA in cholestatic liver disease using liver-specific methylation markers

1 Apr 2021

Abstract excerpt

BACKGROUND: Quantification of circulating organ-specific cell-free DNA (cfDNA) provides a sensitive measure of ongoing cell death that could benefit evaluation of the cholestatic liver diseases primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), which lack reliable non-invasive biomarkers. Our goal in this pilot study was to determine whether liver-specific cfDNA levels are increased in...

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PMID: 33794792
DOI: 10.1186/s12876-021-01741-5

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