Article
MCP-1 and CCR2 gene polymorphisms in Parkinson's disease in a Han Chinese cohort.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Apr 2015
Gao Liang, Tang Hongmei, Nie Kun, Wang Limin, Zhao Jiehao, Gan Rong, Huang Jing, Feng Shujun, Zhu Ruiming, Duan Zhenpeng, Zhang Youwen, Zhao Xin, Zhang Yuhu, Wang Lijuan
Abstract excerpt
Monocyte chemoattractant protein-1 (MCP-1) and its receptor CC chemokine receptor-2 (CCR2) play important roles in neuroinflammation and they have been shown to be involved in Parkinson's disease (PD) pathogenesis. In addition, several studies have suggested a role for the MCP-1 and CCR2 genotypes in cognitive impairment and depression, which are common non-motor symptoms in PD patients. In this study, a cohort...
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