Article
Association between polymorphism c.1-765G>C of the COX2 gene and cognitive impairment in individuals 65 years or more with diabetes from a Geriatric Service in Monterrey, Mexico.
Medicina clinica - 7 Nov 2014
Díaz De León González Enrique, Gutiérrez Hermosillo Hugo, Cedillo Rodrígez Javier Armando, Reyes Romero Miguel Arturo, Camacho Luis Abelardo, Palacios Corona Rebeca, Burciaga Nava Jorge Alberto, Ríos Valles José Alejandro, Tamez Pérez Hector Eloy
Abstract excerpt
BACKGROUND AND OBJECTIVE: Cognitive impairment and dementia are common geriatric syndromes in diabetic patients. Inflammation plays a crucial role in the pathophysiology of Alzheimer's disease and cognitive impairment. Cyclooxygenases (COX) 1 and 2 participate in inflammation. The polymorphism c.1-765G>C of the COX2 gene might be protective against cognitive decline in Mexicans with diabetes mellitus through its...
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