Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors.

doi:10.1038/s41431-017-0050-x

Article

Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors.

European journal of human genetics : EJHG - 1 Feb 2018

Im Cindy, Ness Kirsten K, Kaste Sue C, Chemaitilly Wassim, Moon Wonjong, Sapkota Yadav, Brooke Russell J, Hudson Melissa M, Robison Leslie L, Yasui Yutaka, Wilson Carmen L

Abstract excerpt

Single-nucleotide polymorphisms (SNPs) contributing to interactions between regulatory elements that modulate gene transcription may explain some of the uncharacterized variation for complex traits. We explored this hypothesis among 856 adult survivors of pediatric cancer exposed to curative treatments that adversely affect bone mineral density (BMD). To restrict our search to interactions among SNPs in...

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Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors.

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