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Article

Using biological knowledge to discover higher order interactions in genetic association studies.

Genetic epidemiology - 1 Dec 2010

Chen Gary K, Thomas Duncan C

Abstract excerpt

The recent successes of genome-wide association studies (GWAS) have revealed that many of the replicated findings have explained only a small fraction of the heritability of common diseases. One hypothesis that investigators have suggested is that higher order interactions between SNPs or SNPs and environmental risk factors may account for some of this missing heritability. Searching for these interactions poses...

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PMID: 21104889
DOI: 10.1002/gepi.20542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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