Article
A genome-wide gene-gene interaction analysis identifies an epistatic gene pair for lung cancer susceptibility in Han Chinese.
Carcinogenesis - 1 Mar 2014
Chu Minjie, Zhang Ruyang, Zhao Yang, Wu Chen, Guo Huan, Zhou Baosen, Lu Jiachun, Shi Yongyong, Dai Juncheng, Jin Guangfu, Ma Hongxia, Dong Jing, Wei Yongyue, Wang Cheng, Gong Jianhang, Sun Chongqi, Zhu Meng, Qiu Yongyong, Wu Tangchun, Hu Zhibin, Lin Dongxin, Shen Hongbing, Chen Feng
Abstract excerpt
Lung cancer is the leading cause of cancer-related deaths worldwide. By now, genome-wide association studies (GWAS) have identified numerous loci associated with the risk of developing lung cancer. However, these loci account for only a small fraction of the familial lung cancer risk. We hypothesized that epistasis may contribute to the missing heritability. To test this hypothesis, we systematically evaluated...
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