Article
Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions.
Assay and drug development technologies - 1 Jan 2018
O'Duibhir Eoghan, Paris Jasmin, Lawson Hannah, Sepulveda Catarina, Shenton Dahlia Doughty, Carragher Neil O, Kranc Kamil R
Abstract excerpt
There is a large amount of information in brightfield images that was previously inaccessible by using traditional microscopy techniques. This information can now be exploited by using machine-learning approaches for both image segmentation and the classification of objects. We have combined these approaches with a label-free assay for growth and differentiation of leukemic colonies, to generate a novel platform...
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