Article
Ultra high content image analysis and phenotype profiling of 3D cultured micro-tissues.
PloS one - 1 Jan 2014
Di Zi, Klop Maarten J D, Rogkoti Vasiliki-Maria, Le Dévédec Sylvia E, van de Water Bob, Verbeek Fons J, Price Leo S, Meerman John H N
Abstract excerpt
In many situations, 3D cell cultures mimic the natural organization of tissues more closely than 2D cultures. Conventional methods for phenotyping such 3D cultures use either single or multiple simple parameters based on morphology and fluorescence staining intensity. However, due to their simplicity many details are not taken into account which limits system-level study of phenotype characteristics. Here, we...
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