Article
Sac7 and Rho1 regulate the white-to-opaque switching in Candida albicans.
Scientific reports - 17 Jan 2018
Yang Siwy Ling, Zeng Guisheng, Chan Fong Yee, Wang Yan-Ming, Yang Dongliang, Wang Yue
Abstract excerpt
Candida albicans cells homozygous at the mating-type locus stochastically undergo the white-to-opaque switching to become mating-competent. This switching is regulated by a core circuit of transcription factors organized through interlocking feedback loops around the master regulator Wor1. Although a range of distinct environmental cues is known to induce the switching, the pathways linking the external stimuli...
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