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Article

Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease.

Disease models & mechanisms - 17 Jan 2018

Dobie Ross, MacRae Vicky E, Pass Chloe, Milne Elspeth M, Ahmed S Faisal, Farquharson Colin

Abstract excerpt

Individuals with inflammatory bowel disease (IBD) often present with poor bone health. The development of targeted therapies for this bone loss requires a fuller understanding of the underlying cellular mechanisms. Although bone loss in IBD is multifactorial, the altered sensitivity and secretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in IBD is understood to be a critical contributing...

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Identifiers

PMID: 29343614
DOI: 10.1242/dmm.028456
PMCID: PMC5818069

Genes

SOCS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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