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Article

Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis.

The American journal of pathology - 1 Dec 2006

Han Xiaonan, Osuntokun Bankole, Benight Nancy, Loesch Kimberly, Frank Stuart J, Denson Lee A

Abstract excerpt

Growth hormone (GH) regulates anabolic metabolism via activation of the STAT5b transcription factor and reduces mucosal inflammation in colitis. Peroxisome proliferator-activated receptor (PPAR) gamma suppresses mucosal inflammation and is regulated by GH through STAT5b. We hypothesized that the GH:STAT5b axis influences susceptibility to colitis via regulation of local PPARgamma abundance. Colon biopsies from...

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Identifiers

PMID: 17148664
DOI: 10.2353/ajpath.2006.060186
PMCID: PMC1762482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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