Article
Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease.
International journal of molecular sciences - 3 Dec 2019
Morgan Stephanie, Hooper Kirsty M, Milne Elspeth M, Farquharson Colin, Stevens Craig, Staines Katherine A
Abstract excerpt
Patients with inflammatory bowel disease (IBD) often present poor bone health and are 40% more at risk of bone fracture. Studies have implicated autophagy in IBD pathology and drugs used to treat IBD stimulate autophagy in varying degrees, however, their effect on the skeleton is currently unknown. Here, we have utilised the dextran sulphate sodium (DSS) model of colitis in mice to examine the effects of the...
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