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Article

Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease.

Journal of autoimmunity - 1 Jul 2015

Lempainen Johanna, Laine Antti-Pekka, Hammais Anna, Toppari Jorma, Simell Olli, Veijola Riitta, Knip Mikael, Ilonen Jorma

Abstract excerpt

In addition to the HLA region numerous other gene loci have shown association with type 1 diabetes. How these polymorphisms exert their function has not been comprehensively described, however. We assessed the effect of 39 single nucleotide polymorphisms (SNP) on the development of autoantibody positivity, on progression from autoantibody positivity to clinical disease and on the specificity of the antibody...

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Topics

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Share to Autoantibodies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DEAD-box RNA Helicases

Share to HLA-DQ Antigens

Share to Insulin-Secreting Cells

Share to Interferon-Induced Helicase, IFIH1

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 2

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Source

Identifiers

PMID: 26074154
DOI: 10.1016/j.jaut.2015.05.005

Genes

INS
ERBB3
IFIH1
IKZF4
PTPN2
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease.PMID 26074154Read ↗

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