Article
Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes.
Diabetes - 1 Apr 2018
Kronenberg-Versteeg Deborah, Eichmann Martin, Russell Mark A, de Ru Arnoud, Hehn Beate, Yusuf Norkhairin, van Veelen Peter A, Richardson Sarah J, Morgan Noel G, Lemberg Marius K, Peakman Mark
Abstract excerpt
The signal peptide region of preproinsulin (PPI) contains epitopes targeted by HLA-A-restricted (HLA-A0201, A2402) cytotoxic T cells as part of the pathogenesis of β-cell destruction in type 1 diabetes. We extended the discovery of the PPI epitope to disease-associated HLA-B*1801 and HLA-B*3906 (risk) and HLA-A*1101 and HLA-B*3801 (protective) alleles, revealing that four of six alleles present epitopes derived...
Topics
- Aminopeptidases
- Aspartic Acid Endopeptidases
- Cell Line
- Diabetes Mellitus, Type 1
- Endoplasmic Reticulum
- Epitopes
- Gene Knockout Techniques
- Genetic Predisposition to Disease
- HLA-A Antigens
- HLA-A11 Antigen
- HLA-A2 Antigen
- HLA-A24 Antigen