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Article

New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2013

Oliveira Cláudia C, Querido Bianca, Sluijter Marjolein, de Groot Anne F, van der Zee Reno, Rabelink Martijn J W E, Hoeben Rob C, Ossendorp Ferry, van der Burg Sjoerd H, van Hall Thorbald

Abstract excerpt

The signal peptide peptidase (SPP) is an intramembrane cleaving aspartyl protease involved in release of leader peptide remnants from the endoplasmic reticulum membrane, hence its name. We now found a new activity of SPP that mediates liberation of C-terminal peptides. In our search for novel pro...

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Identifiers

PMID: 24048903
DOI: 10.4049/jimmunol.1301496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24048903-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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