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Article

Consequence of enhanced LC3-trafficking for a live, attenuated M. tuberculosis vaccine.

Vaccine - 8 Feb 2018

Köster Stefan, Klevorn Thais, Papavinasasundaram Kadamba, Sassetti Christopher M, Portal-Celhay Cynthia, Philips Jennifer A

Abstract excerpt

Development of a new vaccine against tuberculosis is urgently needed. Recent work has demonstrated that two related LC3-associated trafficking pathways, autophagy and LC3-associated phagocytosis (LAP), enhance antigen presentation and might play a role in vaccine efficacy. Mycobacterium tuberculosis inhibits both LC3-trafficking pathways. Moreover, the vaccine strain, BCG, induces even less LC3-trafficking than...

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Identifiers

PMID: 29343411
DOI: 10.1016/j.vaccine.2018.01.012
PMCID: PMC5930169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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