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Article

A lipidated peptide of Mycobacterium tuberculosis resuscitates the protective efficacy of BCG vaccine by evoking memory T cell immunity.

Journal of translational medicine - 6 Oct 2017

Rai Pradeep K, Chodisetti Sathi Babu, Zeng Weiguang, Nadeem Sajid, Maurya Sudeep K, Pahari Susanta, Janmeja Ashok K, Jackson David C, Agrewala Javed N

Abstract excerpt

BACKGROUND: The current BCG vaccine induces only short-term protection against Mycobacterium tuberculosis (Mtb), suggesting its failure to generate long-lasting memory T cells. Previously, we have demonstrated that a self-adjuvanting peptide of Mtb (L91), successfully generated enduring memory Th1 cells. Consequently, we investigated if L91 was able to recuperate BCG potency in perpetuating the generation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28985739
DOI: 10.1186/s12967-017-1301-x
PMCID: PMC6389088

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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