Article

SapM mutation to improve the BCG vaccine: genomic, transcriptomic and preclinical safety characterization

2018-12-04

Abstract excerpt

The Mycobacterium bovis Bacille Calmette Guérin (BCG) vaccine shows variable efficacy in protection against adult tuberculosis (TB). Earlier, we have described a BCG mutant vaccine with a transposon insertion in the gene coding for the secreted acid phosphatase SapM, which led to enhanced long-term survival of vaccinated mice challenged with TB infection. To facilitate development of this mutation as part of a fu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8dc9ce07-4d67-57c9-9430-9d3d07435b84
DOI: 10.1101/486993

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SapM mutation to improve the BCG vaccine: genomic, transcriptomic and preclinical safety characterizationDOI 10.1101/486993Read

Genetic Modification of the BCG Vaccine to Overcome Its Limited Efficacy in Adults: A Specialized ReviewSemantic proximity Read

Genetic screening for the protective antigenic targets of BCG vaccination.Semantic proximity Read

Infect and Inject: How Mycobacterium tuberculosis Exploits Its Major Virulence-Associated Type VII Secretion System, ESX-1Semantic proximity Read

Genetic requirements of <i>Mycobacterium tuberculosis</i> for survival under pathogen-specific immunitySemantic proximity Read

Secretory phosphatases deficient mutant of Mycobacterium tuberculosis imparts protection at the primary site of infection in guinea pigs.Semantic proximity Read

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB ProtectionSemantic proximity Read

BCG Vaccines: Their mechanisms of attenuation and impact on safety and protective efficacySemantic proximity Read

Mab_3168c, a putative acetyltransferase, enhances adherence, intracellular survival and antimicrobial resistance of Mycobacterium abscessus.Semantic proximity Read

Genome Sequencing and Analysis of BCG Vaccine StrainsSemantic proximity Read

A comprehensive survey of single nucleotide polymorphisms (SNPs) across Mycobacterium bovis strains and M. bovis BCG vaccine strains refines the genealogy and defines a minimal set of SNPs that separate virulent M. bovis strains and M. bovis BCG strains.Semantic proximity Read

MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB EpidemicSemantic proximity Read

The fbpA/sapM double knock out strain of Mycobacterium tuberculosis is highly attenuated and immunogenic in macrophages.Semantic proximity Read