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Article

Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours

23 May 2017

Abstract excerpt

BACKGROUND: Testicular germ cell tumours (TGCT) are highly sensitive to cisplatin-based chemotherapy, but patients with tumours containing differentiated teratoma components are less responsive to this treatment. The cisplatin sensitivity in TGCT has previously been linked to the embryonic phenotype in the majority of tumours, although the underlying mechanism largely remains to be elucidated. The aim of this...

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PMID: 28536927
DOI: 10.1007/s13402-017-0326-8

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