Article
The Duffy antigen receptor for chemokines regulates asthma pathophysiology.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Sept 2017
Chapman D G, Mougey E B, Van der Velden J L, Lahue K G, Aliyeva M, Daphtary N, George K L, Hoffman S M, Schneider R W, Tracy R P, Worthen G S, Poynter M E, Peters S P, Lima J J, Janssen-Heininger Y M W, Irvin C G
Abstract excerpt
BACKGROUND: The Duffy antigen receptor for chemokines (DARC) is an atypical receptor that regulates pro-inflammatory cytokines. However, the role of DARC in asthma pathophysiology is unknown. OBJECTIVE: To determine the role of DARC in allergic airways disease in mice, and the association between DARC single nucleotide polymorphisms (SNPs) and clinical outcomes in patients with asthma. METHODS: Mice with targeted...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.