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Article

Autoprocessing of HIV-1 protease is tightly coupled to protein folding.

Nature structural biology - 1 Sept 1999

Louis J M, Clore G M, Gronenborn A M

Abstract excerpt

In the Gag-Pol polyprotein of HIV-1, the 99-amino acid protease is flanked at its N-terminus by a transframe region (TFR) composed of the transframe octapeptide (TFP) and 48 amino acids of the p6pol, separated by a protease cleavage site. The intact precursor (TFP-p6pol-PR) has very low dimer stability relative to that of the mature enzyme and exhibits negligible levels of stable tertiary structure. Thus, the TFR...

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Source

Identifiers

PMID: 10467100
DOI: 10.1038/12327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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