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Article

HaSAPPy: A tool for candidate identification in pooled forward genetic screens of haploid mammalian cells.

PLoS computational biology - 1 Jan 2018

Di Minin Giulio, Postlmayr Andreas, Wutz Anton

Abstract excerpt

Haploid cells are increasingly used for screening of complex pathways in animal genomes. Hemizygous mutations introduced through viral insertional mutagenesis can be directly selected for phenotypic changes. Here we present HaSAPPy a tool for analysing sequencing datasets of screens using insertional mutations in large pools of haploid cells. Candidate gene prediction is implemented through identification of...

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PMID: 29337991
DOI: 10.1371/journal.pcbi.1005950
PMCID: PMC5798846

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