Article
Clinical Behavior of Breast Cancer in Young BRCA Carriers and Prediagnostic Awareness of Germline BRCA Status.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2025
Lambertini Matteo, Blondeaux Eva, Tomasello Loredana M, Agostinetto Elisa, Hamy Anne-Sophie, Kim Hee Jeong, Franzoi Maria Alice, Bernstein-Molho Rinat, Hilbers Florentine, Pogoda Katarzyna, Wildiers Hans, Bajpai Jyoti, Ignatiadis Michail, Moore Halle C F, Partridge Ann H, Phillips Kelly-Anne, Toss Angela, Rousset-Jablonski Christine, Criscitiello Carmen, Renaud Tiphaine, Ferrari Alberta, Paluch-Shimon Shani, Fruscio Robert, Cui Wanda, Wong Stephanie M, Vernieri Claudio, Ruddy Kathryn J, Dieci Maria Vittoria, Matikas Alexios, Rozenblit Mariya, Villarreal-Garza Cynthia, De Marchis Laura, Puglisi Fabio, Rodriguez-Wallberg Kenny A, Duhoux Francois P, Livraghi Luca, Bruzzone Marco, Boni Luca, Balmaña Judith
Abstract excerpt
PURPOSE: To investigate the clinical behavior of breast cancer in young BRCA carriers according to the specific BRCA gene (BRCA1 v BRCA2) and the association of the timing of genetic testing (before v at diagnosis) with prognosis. METHODS: This was an international, multicenter, hospital-based, retrospective cohort study that included 4,752 patients harboring germline pathogenic/likely pathogenic variants (PVs)...
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