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Article

Two decades after BRCA: setting paradigms in personalized cancer care and prevention.

Science (New York, N.Y.) - 28 Mar 2014

Couch Fergus J, Nathanson Katherine L, Offit Kenneth

Abstract excerpt

The cloning of the breast cancer susceptibility genes BRCA1 and BRCA2 nearly two decades ago helped set in motion an avalanche of research exploring how genomic information can be optimally applied to identify and clinically care for individuals with a high risk of developing cancer. Genetic testing for mutations in BRCA1, BRCA2, and other breast cancer susceptibility genes has since proved to be a valuable tool...

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Topics

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Genetic Predisposition to Disease

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Source

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Identifiers

PMID: 24675953
DOI: 10.1126/science.1251827
PMCID: PMC4074902

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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