Article
Clinicopathological features and BRCA1 and BRCA2 mutation status in a prospective cohort of young women with breast cancer.
British journal of cancer - 1 Feb 2022
Guzmán-Arocho Yaileen D, Rosenberg Shoshana M, Garber Judy E, Vardeh Hilde, Poorvu Philip D, Ruddy Kathryn J, Kirkner Gregory, Snow Craig, Tamimi Rulla M, Peppercorn Jeffrey, Schapira Lidia, Borges Virginia F, Come Steven E, Brachtel Elena F, Marotti Jonathan D, Warner Ellen, Partridge Ann H, Collins Laura C
Abstract excerpt
BACKGROUND: Breast cancer in young women is more likely to have higher risk features and be associated with germline BRCA1/BRCA2 mutations. We present the clinicopathologic features of breast cancers in a prospective cohort of young women, and associations between surrogate molecular subtype and BRCA1/BRCA2 mutation status. METHODS: Histopathological features, biomarker status, tumour stage and BRCA status were...
Topics
- Adolescent
- Adult
- Age Factors
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Estrogen Receptor alpha
- Female
- Humans