Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Management Strategies of Breast Cancer Patients with BRCA1 and BRCA2 Pathogenic Germline Variants

1 Jul 2022

Abstract excerpt

Abstract: Most of breast cancer cases are sporadic; however, 15– 20% are associated with family history, and some are inherited. Among those, deleterious mutations in BRCA1 and BRCA2 tumor suppressor genes are the most commonly encountered pathogenic germline variants (PGVs). Given the availability and affordability of multi-gene panel sequencing technologies, testing for PGVs is commonly practiced. With our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA gene mutations in cancer
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35923470
DOI: 10.2147/ott.s369844

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Management Strategies of Breast Cancer Patients with BRCA1 and BRCA2 Pathogenic Germline VariantsPMID 35923470Read ↗

BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies.Semantic proximity Read ↗

Germline Testing in Patients With Breast Cancer: ASCO-Society of Surgical Oncology Guideline.Semantic proximity Read ↗

Prevention, diagnosis and clinical management of hereditary breast cancer beyond BRCA1/2 genes.Semantic proximity Read ↗

BRCA1, BRCA2, and Associated Cancer Risks and Management for Male Patients: A Review.Semantic proximity Read ↗

Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.Semantic proximity Read ↗

Germline Pathogenic Variants in BRCA1 and BRCA2: Malignancies Beyond Female Breast and Ovarian Cancers.Semantic proximity Read ↗

Management of breast cancer risk in BRCA1/2 mutation carriers who are unaffected with cancer.Semantic proximity Read ↗

Germline BRCA testing is moving from cancer risk assessment to a predictive biomarker for targeting cancer therapeutics.Semantic proximity Read ↗

Utility of Expedited Hereditary Cancer Testing in the Surgical Management of Patients with a New Breast Cancer Diagnosis.Semantic proximity Read ↗

Genetics of breast cancer: management strategies and risk-reducing surgery.Semantic proximity Read ↗

Cancer treatment according to BRCA1 and BRCA2 mutations.Semantic proximity Read ↗

Genetic testing in women with breast cancer: implications for treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.