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Article

Association Between the Interferon Gamma 874 T/A Polymorphism and the Severity of Valvular Damage in Patients with Rheumatic Heart Disease.

Biochemical genetics - 1 Jun 2018

Teker Erhan, Akadam-Teker A Basak, Ozturk Oguz, Eronat Allison Pinar, Yalin Kivanc, Golcuk S Ebru, Bugra Zehra

Abstract excerpt

Interferon gamma (IFN-γ) is a multifunctional cytokine that plays an important role in modulating almost all phases of the immune response and may be responsible for the increased valvular fibrosis and calcification in the pathogenesis of rheumatic heart disease (RHD). The aim of this study was to investigate the possible relationship between the IFN-γ +874 T/A polymorphism and the severity of valvular damage in...

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Source

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PMID: 29332266
DOI: 10.1007/s10528-017-9839-0

Genes

RHD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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